Chunk #18 — RESULTS — Adolescents at higher genetic risk were more likely to convert to daily smoking early and to progress rapidly from initiation to smoking ≥20 cigarettes/day

Source

Polygenic risk and the developmental progression to heavy, persistent smoking and nicotine dependence: evidence from a 4-decade longitudinal study.

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Among ever-smokers, 19% converted to daily smoking by age 15 years (early conversion) and 10% progressed to smoking ≥20 cigarettes/day by age 18 years (rapid progression to heavy smoking). Each unit increase in the GRS predicted a 24% increase in the relative risk of early conversion (RR=1.24 [1.06-1.45]) and a 43% increase in the relative risk of rapid progression (RR=1.43 [1.10-1.86]).