There has been some discussion on the applicability of screening instruments in different settings (research vs. clinical). For example, in the original publication Gossop et al. [12] explicitly recommend the SDS for research purposes and not for clinical use. In recent times however, increasing evidence suggests its utility as a clinical and research tool [33]. Screens can be specifically useful in clinical settings as their results can determine further steps in the individual assessment or treatment planning. Those patients with a positive screening result can be referred to more extensive diagnostic assessments of cannabis dependence (for example CIDI). Patients, for whom the CIDI assessment does not confirm the screening result, may still experience negative consequences from their cannabis use. These individuals do not need full treatment but may be referred to brief interventions. In the case of cannabis, further studies need to assess the performance of screening scales in different clinical settings.