Table S3).Table 2Prediction accuracy of the trans-ancestry T2D PRS in eMERGE across three populationsPopulationLiabilityR2Covariates-adjusted AUCOR per SD(95% CI)Top 2% PRSOR(95% CI)P valueSensitivitySpecificityAdjusted PPV*Adjusted NPV*European9.2%0.661.96(1.91, 2.02)4.21(3.66, 4.84)1.82E−890.050.990.260.90African2.8%0.581.54(1.46, 1.64)1.98(1.43, 2.74)4.34E−050.030.980.210.88Hispanic8.0%0.632.08(1.84, 2.35)6.87(3.11, 15.15)1.81E−060.040.990.430.87*Adjusted PPV and NPV are calculated using the following population-specific prevalence: European 10%; African 12.5%; Hispanic 13.1%
