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Chunk #9 — RESULTS — Expression and developmental regulation of NHE9 in brain

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Functional evaluation of autism-associated mutations in NHE9.
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to the p1 region by P28. Finally, the adult brain is primarily composed of two broad classes of cells: neurons and glial cells. We compared the mRNA transcript levels of NHE9 in neurons and astrocytes, the most abundant macroglial cells in the cortex. NHE9 expression was ~1.2 fold higher in astrocytes relative to the neurons (Figure 4D).