Results revealed 1 and 69 independent QSNP loci for the p-factor and neuroticism, respectively (Figure 2c and Figure 2d; Supplementary Figure 14). For neuroticism, significant QSNP estimates were obtained for SNPs that were highly significant for some traits but not others (Supplementary Table 7; Supplementary Figure 15). The association between p-values for SNP effects and QSNP estimates were minimal (Supplementary Figure 16). Comparing the QSNP estimates for SNPs identified as significant for only the p-factor or neuroticism relative to SNPs identified as significant for one of the indicators, but not the common factor, indicated that the latter group of SNPs were characterized, as would be expected, by larger QSNP estimates (i.e., greater heterogeneity in individual effects; Supplementary Figure 17). Intercepts from LDSC analyses of the QSNP statistics also indicated that results for the heterogeneity index were not attributable to inflation (p-factor: intercept = .978, SE = .009; neuroticism: intercept = .963, SE = .009). Slopes from the same LDSC analyses further indicated genetic signal in heterogeneity (p-factor: Z = 13.65, p-value = 6.68E-42; neuroticism: Z = 30.23, p-value = 9.98E-201).
