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Chunk #27 — BK subunit composition predicts alcohol acute tolerance and consumption

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BK Channels: mediators and models for alcohol tolerance.
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mice drank markedly more than their wild type counterparts (Figure 4d, BK β4 KO). There was no difference found in baseline fluid (water and sucrose) intake in WT and KO mice. These studies underline the concept that alcohol consumption can be linked to the functional properties of an ion channel protein.