Note that PRODH and DGCR6¸which map very closely to each other (25 kb), were the top two connecting deleted genes in the adolescence stage. Previous association analyses of various segments in the 22q11 deleted region using polymorphic markers for fine-scale mapping in heterogeneous U.S. family samples, determined that markers near PRODH and DGCR6 were associated with SZ, providing strong evidence for a contribution of the PRODH/DGCR6 locus in 22q11-associated SZ [14].
