Chunk #28 — Identifying Specific Genes Related to AOD Dependence — Genes Encoding Proteins Involved in Neurotransmission — Genes Involved in the Endogenous Cannabinoid System
Zhang et al. 2004) and others producing negative results (e.g., Herman et al. 2006). Most recently, Hopfer and colleagues (2006) found that a SNP in the CNR1 gene was associated with cannabis dependence symptoms. 6 Moreover, this SNP was part of several sets of multiple alleles that are transmitted jointly (i.e., haplotypes), some of which are associated with developing fewer dependence symptoms, whereas others are associated with an increased risk for cannabis dependence. Finally, a recent case–control study found that multiple genetic variants in CNR1 were significantly associated with alcohol dependence and/or drug dependence (Zuo et al. 2007).
