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Chunk #23 — Methods — Genome-wide associations.

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Minimal phenotyping yields genome-wide association signals of low specificity for major depression.
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To obtain and access the difference between ORs of associations in different definitions of depression in the UK Biobank, as well as for smoking (data field 20160) and neuroticism (data field 20127), we performed logistic regression (or linear regression with –standard-beta for neuroticism) on all 5,276,842 common SNPs (MAF > 5% in all 337,198 White-British unrelated samples) in PLINK65 (version 1.9) with 20 principal components and genotyping array as covariates.