Chunk #76 — Experimental Procedures — Population structure of recurrent de novo CNVs

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Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism.

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All parents were projected onto a five-dimensional ancestry map using eigenvector decomposition (Crossett et al., 2010; Lee et al., 2009). Euclidean distances were measured for the parent-of-origin. The mean and median distances between these pairs of parents were calculated and were evaluated relative to the remainder of the sample using a bootstrap procedure (supplementary methods).