Whether ARBD represents one end of a continuum of neurological deficits, with disorders such as KS and MBD at the other end,5 or one outcome in a range of dis continuous, graded deficits occurring with chronic alcohol exposure and, for example, aging6 remains unclear. In addition, whether people with certain genotypes (for example, individuals who are genetically susceptible to mal nutrition or liver compromise) are at a greater risk of particular neuro logical conditions and, consequently, are more likely to express specific alcoholism-related neuropsychological compromise than are individuals with a different genetic make-up remains to be determined. Our objective here is to describe a potential continuum between ARBD, WE and KS with respect to changes in human behavior and brain structure. Note that while this Review is extensive, it is not intended to be exhaustive.
