In neuroscience, one of the main interests is how epigenetic information is processed and recorded as plasticity within a network pattern, and how changes in the network patterns relate to plasticity. Thus, for many years, neurobiologists have investigated single-cell-based neuronal network cultivation and examined the firing patterns of single neurons through the fabrication of cultivation substrates using microprinting techniques [69-71], patterning on silicon-oxide substrates [72], and three-dimensional structures made using photolithography [73]. Although these conventional microfabrication techniques provide structures with fine spatial resolution, effective approaches for studying epigenetic information are still being sought. With conventional techniques, it is still hard to make flexible microstructures with simple steps or to change their shape during cultivation since the shape is usually unpredictable and only defined during cultivation.
