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Chunk #45 — Materials and Methods — Sensitivity analyses

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Discovery of novel heart rate-associated loci using the Exome Chip.
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A sensitivity analysis was performed on the use of beta-blockers (ATC code C07) due to the recognized effects of beta-blockers on HR. All cohorts with data on beta-blocker use were re-analysed with exclusion of individuals using beta-blockers at the time of phenotype measurement. Results of this meta-analysis were compared with the results from the same subset of cohorts with beta-blocker users included.