For locus 1 (rs16969968), we see an ordinal effect with increasing CPD; that is, the odds ratio increases from 1.15 to 1.29 to 1.40 for categories 2, 3 and 4, with a corresponding decrease in p-value from 3.17×10−8 to 2.12×10−12 to 5.47×10−40. A similar ordinal effect is seen for locus 2 (rs578776), with the odds ratio decreasing from 0.88 to 0.79 to 0.77. For locus 3 (rs588765) we see an effect only with the highest smoking category (CPD>30). For locus 4 no effect is seen across smoking categories, consistent with the dichotomous CPD results.
