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Chunk #27 — Discussion

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Positive Selection on Loci Associated with Drug and Alcohol Dependence.
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iHS values. Extreme values of iHS are unlikely under simple demographic models, and thus can indicate the action of an ongoing selective sweep. Despite the fact that none of the populations had significantly different p-values from the negative control in the chromosome 8 region, a few key SNPs did have extreme values. Together, these data imply that the Tajima’s D analysis is picking up on ongoing positive selection rather than balancing selection.