Single-SNP association analyses were performed under an additive genetic modelseparately within each of the 15 datasets (Supplementary Information). We tested for association across the autosomes and the non-pseudoautosomal region of the X chromosome. Imputation and association analysis of the non-pseudoautosomal region of the chromosome X data were based on females (2,907 AN cases and 10,594 controls). Association analyses were performed using SNPTEST v2.2.049 under an additive model and using a score test. To guard against false positives due to population stratification, we carried out association analysis within each dataset and then combined the results using meta-analysis (for the French dataset, the first principal component was added as a covariate). Fixed-effects meta-analyses were performed using GWAMA.50 All 15 discovery datasets were corrected for the genomic control (GC) inflation factor (λGC) prior to performing meta-analysis (Table S2; Supplementary Information).
