oligodendrocytes of the white and gray matter14,15. The mouse strain expressing the hGFAP-EGFP (kind gift of F. Kirchhoff, Max Planck Institute of Experimental Medicine, Goettingen, Germany) was previously characterized31. The EGFR-mutant mouse (waved-2 mutation; Wa2)32 was obtained from Jackson Labs (Bar Harbor, ME). All animalprocedures were performed according to the Institutional Animal Care and Use Committee of Children’s National Medical Center and the National Institutes of Health “Guide for the Care and Use of Laboratory Animals.”