Functional mapping and annotation of the 6 GWAS hits using the FUMA pipeline conservatively predicted five genes ZDHHC14, PARK2, KAZN, TMEM51-AS1 and ZNF813 located in EUA risk loci, and five distinct genes LINC02335, MIR5007, TUC338, LINC02571 and HLA-B in AFA risk loci (Table 4). In addition, gene-based analyses on 18,222 protein-coding genes based on the EUA and AFA GWAS summary data identified two additional gene-wide significant loci, represented by SH3RF3 (P = 4.28 × 10−07) and PODXL (P = 2.37 × 10−06) in the EUA analysis. Gene-based analyses in AFA did not result in genome-wide significant loci. The biological function and potential psychiatric relevance of the 12 genes predicted by FUMA are detailed in the Supplementary Note 1 and discussed below.Table 4Functional mapping and annotation of GWAS meta-analyses in the European and African ancestry dataGroupGWAS hit lead variant#SNPs in LD (r2 > 0.6)genomic coordinate risk locus (hg19)predicted genes in risk locusSNPs in LD with CADD scores > 12.37SNPs in LD with RegulomeDB scores < 5Chromatin state analysis (Roadmap Epigenomics) in neuronal cell lines/tissuesaeQTLHi-C in 3 neuronal tissue/ cell line datasets,
