In conclusion, this study adds support for the role of ADH1B and ADH1C in alcohol phenotypes in a large Israeli household population. Further, the results suggest that considering these SNPs together provides a model that more accurately depicts the polygenic architecture of AUD traits. Studies of the association of alcohol phenotypes and either ADH1B or ADH1C alone are employing an oversimplified model, which may mask relevant information regarding the genetic influence of these ADH variants on behavioral alcohol phenotypes.
