are differentially associated with internalizing and thought disorder psychopathology. Finally, the definitions of cases in the GWAS used in this study include any person who meets criteria for the relevant diagnosis without regard to comorbid conditions for which they may also meet criteria. High rates of phenotypic correlations and comorbidity among psychiatric disorders suggest a high likelihood that many individuals designated as cases in, for example, the AUD GWAS, also had other psychiatric diagnoses. This means that univariate GWAS necessarily tag genetic variance related to other, correlated traits that is not explicitly modelled by genomic SEM.
