Alternative mRNA splicing is the process where a single gene codes for multiple mRNA transcripts and consequently multiple proteins and gene isoforms with different structures and functions. Nearly 95% of human genes undergo alternative splicing1. Alternative mRNA splicing in the brain is a major contributor to both the genetic and neuromolecular pathology of psychiatric traits2. But researchers rarely investigate genome-wide or transcriptome-wide alternative mRNA splicing associations with substance use disorders.
