The primary strength of this investigation is to have extended prior work by increasing sample size via collaboration. Importantly, our combined sample size remains modest given contemporary understanding of complex trait genetics. Moreover, since our collection represents all of the currently GWAS genotyped anorexia nervosa samples in the world, no known genotyped replication samples exist. As such, we expect this to be the beginning of genomic discovery in eating disorders (25). Future work with additional and better-powered anorexia nervosa GWAS will clarify the magnitude of genetic relationships among metabolic and psychiatric phenotypes and methods such as that proposed by Pickrell et al. (40) will provide clues about the direction of causal relationships.
