The SNP with the strongest association to schizophrenia (rs1198588) is 39kb upstream of MIR137, and might regulate the transcription of MIR137. However, this has not been proven experimentally and there is another candidate gene in the region. rs1198588 is in an LD block that includes DPYD (169kb upstream of rs1198588),and rs1198588 is a significant local expression quantitative trait locus (eQTL) with DPYD. We note that DPYD also contains a predicted miR-137 target site. An exome sequencing study reported two putative functional de novo variants in DPYD in cases with schizophrenia. 11
