Chunk #20 — 3. Results — 3.3. PPARα activators influence mRNA levels of pro-inflammatory molecules after LPS injection

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Effects of chronic systemic treatment with peroxisome proliferator-activated receptor α activators on neuroinflammation induced by intracerebral injection of lipopolysaccharide in adult mice.

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We also measured mRNA levels of cell adhesion molecules: ICAM-1, VCAM-1, and PECAM-1. LPS elevated all of the three molecules at 6 hours and the elevations of ICAM-1 and PECAM-1 were more pronounced at 3 days (Figs. 3G–I). Again, Wy-14643 and fenofibrate significantly inhibited these elevations.