MSNs, with a smaller cell body, less expansive dendrite structure, and fewer spines, and were differently affected by treatment with a denervating agent.63 Genes involved in collagen-containing extracellular matrix and vesicular pathways were upregulated in those with AUD. Collagen is a major component of the blood-brain barrier,65 so these neurons could play a role in its integrity or regulation, processes which may be disrupted in AUD.
