Several other SNPs attained genomewide significance in some analysis phases or in specific subgroups or were nearly GWS. We observed association of the DSM-IV diagnosis of CD with two SNPs near RANP6 (rs4129566 and rs11944332) in the AA discovery sample (4.26×10−7 and 4.11×10−7, respectively) and the Phase 3 EA sample (p=1.92 ×10−4 and 2.17×10−4, respectively). In the EA discovery sample, CD was also associated with rs6677435 (2.18×10−7), located approximately 400 kb from its nearest gene, KCNT2, which encodes a potassium voltage-gated channel that we previously reported to be associated (p=2.1×10−7) with OD in AAs.7 There was also evidence of association with rs1757939 (p=7.88×10−7) in the AA discovery sample. This SNP is approximately 132kb 5′ of SCLT1, which encodes a protein that links the voltage-gated sodium channel Na(v)1.8 with clathrin. Other notable associations include that of CDK1 (cyclin-dependent kinase 1, a serine/threonine protein kinase) and cocaine-induced paranoia (4.86×10−8 in AAs and 0.0502 in EAs), and NCOR2 (nuclear receptor corepressor 2) and CD symptom count (p=1.19×10−9 in EAs). These Phase 1 (discovery sample) results, some reaching GWS, were not replicated. Although these
