Chunk #107 — III. Selected Methodological Issues — C. Analyses — 1. Achieving significant genome wide association in single samples vs seeking replication and generalization in multiple samples
This approach seeks to identify genes with variants that are likely to play roles in addiction and in related phenotypes. This approach allows for “locus heterogeneity”, and thus does not use the more stringent criterion that the same SNP is required to display nominal significance in each of the samples in which association data is said to support association at a specific gene locus. This approach allows for differences in phase of association, and thus does not use the more stringent criterion that the same allele of the SNP (or haplotype) must be associated with nominal significance in each of the samples in which association data is said to support association at a specific gene locus. The approach allows for different details of the patterns of linkage disequilibrium between marker and functional haplotype from sample to sample. The approach allows us to combine datasets in which different marker sets are used. With each of these limitations, it is clear that subsequent followup analyses are required. Analyses in the same and in additional independent samples are required to untangle any locus
