While it must be kept in mind that there are generally no neat boundaries separating the subregions of the PFC, the human PFC can be grossly localized to specific Brodmann areas of the frontal cortex. The lateral PFC is composed principally of parts or all of Brodmann areas 8, 9, 10, and 46, and the medial PFC is composed principally of parts of areas 8, 9, 10, and 12, with areas 24, 25, and 32 forming the anterior cingulate (ACC). The orbitofrontal cortex (OFC) is the ventral portion of the frontal cortex on the dorsal surface of the orbit and is comprised of areas 11, 12, 13, and 14.
