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Chunk #15 — MATERIALS AND METHODS — Linear discriminant functions by optimal scoring

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Classification and selection of biomarkers in genomic data using LASSO.
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As mentioned before, a problem with attempting to apply standard linear discriminant function methods to the data here is that there is not a numerically unique solution because p is larger than n. Thus, some type of regularization is needed. Our approach is based on the LASSO, which is described in the next section.