The in situ expression data in the ABA shows a striking spatial correlation between expression of Kcnj9 and other seizure-related transcripts that have trans-QTLs in Qrr1p. The complementary expression of Kcnj9 and the seizure-related transcripts (figure 8) make Kcnj9 a stronger candidate than Kcnj10. Kcnj9 has over a 2-fold higher expression in D2 [our data],[and cf. 26,86], a seizure prone strain, compared to B6, a relatively seizure resistant strain, suggesting that the proximal cause of Szs1 may be high expression of this gene, perhaps due to the promoter polymorphism discovered by Hitzemann and colleagues [26].
