paperKB
coga / coga-kb
Processing
Help
Sign in

Chunk #17 — Results — Distinctive Maturation‐Specific Changes in Functional Ion Channel Expression in hPSC‐Derived Oligodendrocyte‐Lineage Cells

Source
Maturation and electrophysiological properties of human pluripotent stem cell-derived oligodendrocytes.
Embedded
yes

Text

lines (For I K; iPS1, 2.9 ± 1.2%, iPS2, 7.0 ± 1.1%, n = 4–6, N = 2, and for I A; iPS1, 0.8 ± 0.4%, iPS2, 5.0 ± 0.5%, n = 3–9, N = 2–9, p<0.001 in all cases, Mann‐Whitney U tests). I A and I K currents were detected in all PDGFRα+‐OPCs. In ESC‐derived week 3 O4+‐oligodendrocytes expression of I A and I K currents were observed in 78% and 83% of cells, respectively, whereas in iPSC‐derived week 3 O4+‐oligodendrocytes I A and I K currents were seen in 83% and 67% of cells, respectively.