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Chunk #3 — INTRODUCTION

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DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212.
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tempo of development of newborn dentate granule cells, including over-extended migration, accelerated axon and dendrite development as well as synapse formation (Duan et al., 2007; Faulkner et al., 2008). The signaling mechanisms by which DISC1 regulates different aspects of neuronal development in vivo remain elusive.