By combining AAOS and CSF biomarker GWAS results, we provide evidence of AD association at additional loci (Table 2). In particular, rs7867518 at the VLDLR locus shows suggestive associations with both AAOS (P=9.1×10−6) and CSF tau (P=3.03×10−3). An adjacent SNP (rs2034764) in the neighboring gene, KCNV2, has been previously reported to have suggestive association with AAO22. VLDLR is a receptor for lipoproteins containing APOE38 and CLU/APOJ39, another AD risk gene. Additionally, the VLDLR-5-repeat allele was found to be associated with dementia38. This genetic and biochemical evidence suggests VLDLR may be linked to AD.
