Chunk #75 — III. Specific Genes for Aggressive Behavior: Findings from Molecular Genetic Studies — A. G × E interaction involving specific genes for aggressive behavior
Foley et al. (2004), Haberstick et al. (2005), Kim-Cohen et al. (2006), and Nilsson et al. (2006). The association between maltreatment and mental health problems was significantly stronger in the group of males with a genotype conferring low versus high MAO-A activity. This provides strong evidence that the MAO-A gene influences vulnerability to environmental stress and that this biological process can be initiated early in life. However, there is at least one published failure to replicate (Haberstick et al., 2005), and this finding has been replicated neither in females (Sjöberg et al., 2007) nor in African Americans (Widom and Brzustowicz, 2006).
