Since completion of our meta-analysis of Exome Chip genotypes, a genome-wide scan for HR has been completed in UK Biobank (17). This study published 46 new HR loci. Four of these novel loci were simultaneously discovered in our analyses (RNF207, SCN10A, 5p13.3, KDELR3:Table 1B). Among the 42 remaining UK Biobank loci, only five of the lead SNVs were covered on the Exome Chip at r2 ≥ 0.8. Results from our exome RR European-ancestry meta-analyses show support for all five of these loci (P < 0.01; Bonferroni-adjusted significance for five tests; Supplementary Material, Table S6).
