Although we found ITC reduction in association with familial risk effects, others have reported ITC alteration in association with prenatal exposure to alcohol. Chen et al., (2012) reported lesser gray matter volume of right ITC among young adults who were prenatally exposed in comparison to healthy controls. Similarly, Zhou et al., (2011) showed lesser cortical thickness and higher age related cortical thinning in left ITC in participants with fetal alcohol spectrum disorder. However, neither of these studies investigated the role of familial risk for AD.
