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Chunk #55 — Materials and Methods — Data preprocessing.

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Mapping the genetic architecture of gene expression in human liver.
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Age. Ages were imputed using the Elastic Net method [47]. This method performs model selection and parameter estimation in a manner that is a combination of ridge-regression and the lasso. The prediction method is also explained in [47]. For computational reasons, λ was set to zero, in which case the Elastic Net method reduces to the lasso method. For most applications, experience demonstrates that the optimal value for λ is zero or quite near zero.