Chunk #58 — Conclusions

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Characterizing and measuring bias in sequence data.

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Formulation of a menagerie of 'bad' motifs: these encode known trouble spots, including high and low GC but also less well-known motifs, such as ATAT... runs. GC-bias plots effectively encode a whole family of motifs, one for each GC percentage. Motifs, especially on large genomes such as human, can be economically assayed using low-coverage data.