Smokers with low FKBP5 mRNA had a blunted HR response to nicotine (group-by-dose interaction; F(2,887)=7.8; P<0.0005) (Figure 2B). The HR effect was most evident in the minute following nicotine administration. There was also a modest mRNA-by-dose effect on systolic BP (group-by-dose interaction; F(2,908)=4.7; P<0.01) (Supplementary Figure S3). The HR effects were independent of genotype, baseline cortisol levels, array number, cigarette pack-years, and RNA Integrity Number, which were entered into the models in post-hoc analyses. FKBP5 genotype was not associated to HR or BP outcomes (Supplementary Figure S3).
