lobe regions) that are involved in the processes of executive control and motivation.168 Heavy alcohol use during adolescence is associated with a range of neurobehavioural sequelae, including impairments in visuospatial processing, attention, and memory,173,174 and adolescents who had engaged in episodes of heavy drinking presented faster declining volumes in some neocortical grey matter regions and smaller increases in regional white matter volumes than did non-drinking adolescents.175 Additionally, voluntary binge drinking in animal models during adolescence reduced the density of myelinated axons in the medial prefrontal cortex.176
