Chunk #29 — Methods — Analytical methods — SMA models

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The CHRNA5/A3/B4 gene cluster and tobacco, alcohol, cannabis, inhalants and other substance use initiation: replication and new findings using mixture analyses.

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Sex was also included as a covariate in all models to account for potential gender differences in age of onset. The models are labeled as follows. Depending on whether a single or 2-class model is fitted, C1 or C2 is appended to M1–M3, leading to model labels M1C1, M1C2, M2C1, etc. (see Table 1).