Chunk #48 — Materials and Methods — Population genetics analysis (varLD and Heterozygosity)

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High trans-ethnic replicability of GWAS results implies common causal variants.

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We used a similar sliding window approach to summarize the differences in allele frequencies between Europeans and East Asians. Again, we did it for each SNP, calculating the average heterozygosity in each window for replicated and non-replicated SNPs. Differences in heterozygosity are simply the result of subtracting the average heterozygosity in East Asians from that in Europeans (Figure 2).