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Chunk #5 — Results — Genome-Wide Association Study for Circulating Adiponectin Levels

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A genome-wide association study reveals variants in ARL15 that influence adiponectin levels.
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Our results also identified a novel intronic SNP (rs4311394) located in the ARL15 (ADP-ribosylation factor-like 15) gene whose G allele was robustly associated with decreased adiponectin levels (P = 2.9×10−8) (Table 2, Table S3, Figure 2). ARL15 is an ADP-ribosylation factor-like GTP-binding protein, whose function is unknown, yet belongs to a family of proteins involved in intracellular vesicle trafficking [19].