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Chunk #6 — Introduction

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Contrasting influences of Drosophila white/mini-white on ethanol sensitivity in two different behavioral assays.
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Given the use of the fly as a model for ethanol-related behaviors and the wide-spread use of mini-w as a transgenic marker in flies, we explored the contribution of mini-w and endogenous w expression to ethanol sensitivity in two different behavioral assays. We find that ethanol sensitivity measured by loss of climbing in flies is significantly influenced by mini-w and endogenous w, whereas ethanol sensitivity measured by sedation is not.