In addition to being influenced by societal conditions or familial background, there are also intrinsic biological and behavioural determinants that may increase a person’s likelihood of developing substance use disorders. Variations in biological pathways and certain genetic polymorphisms have been associated with the onset of dependence [38]. Psychological characteristics such as reward or sensation seeking, decision-making, behavioural disinhibition, and impulsivity are also significant intrinsic contributors to dependence [38-40, 45].
