Our findings clearly indicate lateral spread of the LFP well beyond the 200~400 μm range, with a vertical spread also extending many millimeters beyond auditory cortex. These findings challenge the notion that LFPs can be generally assumed to represent very local neuronal processes. They emphasize the critical importance of considering technical factors such as reference electrode location, as well as physiological factors such as the spatial extent/configuration and activation strength/symmetry of the underlying neuronal generators, in the interpretation of LFP recordings.
