PKC inhibition attenuates psychostimulant-induced hyperlocomotion. Intra-NAc infusion of the PKC inhibitor Ro31-8220 inhibits hyperlocomotion induced by amphetamine in rats.174 In cocaine-sensitized rats, cocaine-induced hyperlocomotion is also attenuated by intra-NAc injection of the PKC inhibitor BIS.174 Co-administration of the PKC inhibitor NPC 15437 with repeated injections of methamphetamine attenuates the development of locomotor sensitization in mice.181
