Frequent heavy alcohol use can lead to alcohol use disorder (AUD), which accounts for three million deaths and over 133 million life years lost to disability and death worldwide per year (WHO, 2018). Modest levels of alcohol consumption are also associated with health consequences, especially in younger age demographics (Bryazka et al. 2022). Alcohol use is under significant genetic influence, with genetic factors accounting for approximately 50% of the variability in risk for heavier alcohol consumption (Verhulst et al. 2015). Accordingly, many studies have been conducted to identify the underlying genetic variants that contribute to the propensity for alcohol use.
