paperKB
coga / coga-kb
Help
Sign in

Chunk #34 — Methods — Genetic mapping

Source
The Netrin-1 receptor DCC is a regulator of maladaptive responses to chronic morphine administration.
Embedded
yes

Text

Integration of computational genetic mapping results across related traits- To measure the overall association of a gene with multiple related traits, HBCGM was first applied to evaluate each trait. The number of times any region corresponding to this gene was associated with a trait of interested (p < 0.01) was counted. To take the strength of association into account, a score similar to that defined for robustness test was also calculated: , where i runs through all traits of interest and pi was defined as previously described. In general, genes with multiple highly significant associations have high scores and therefore are of higher interest.