paperKB
coga / coga-kb
Help
Sign in

Chunk #26 — RESULTS — Biomarker replication is influenced by blood cellular heterogeneity

Source
Antenatal prediction of postpartum depression with blood DNA methylation biomarkers.
Embedded
yes

Text

(Spearman’s ρ=0.24, P=0.36). We limited the analysis to only those 11 samples where CBC data was derived from within the same trimester as the blood draw used for microarray analysis and observed a significant correlation (Spearman’s ρ=0.66, P=0.044). We attempted to predict PPD status via bootstrap analysis across all 17 individuals using the linear model generated above with CBC data-based monocyte to non-monocyte ratios in place of proxy-based ratios and generated a highly accurate prediction of PPD status (AUC=0.96) (Figure 3d).